In addition, several studies reported that nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasome activation is an important player in AT inflammation, as it contributes to obesity-induced inflammation and is linked to insulin resistance and atherosclerosis in mice and humans [10, 15–19]. This evidence concerns the gene NLRP3 and obesity due to melanocortin 4 receptor deficiency.