HK2 and chronic myelogenous leukemia, BCR-ABL1 positive: Examination of Glut1, HKII, PKM2, and PFKP expression levels in CML cells treated with combined Chi and IM revealed a downregulation of Glut1 and a substantial decrease in pyruvate kinase PKM2 expression in both cell types following the combined strategy (Fig. 6b).