Consistent with the mostly negative correlation between UFSP2 protein and gene expression levels in AD brain, Bip, PERK, ATF4, CHOP, IRE1α, and Xbp1s were all increased in UFSP2 KO neurons, while ATF6 levels were decreased (Fig. 5B,C). Here, EIF2AK3 is linked to Alzheimer disease.