The negative correlation between soluble UFSP2 and insoluble UFM1 was also conserved in the larger cohort (Fig. 2B) and present in both brain regions in all three groups (controls, AD, and when combining all subjects) and remained significant in multivariable linear regression models and upon adjusting for multiple testing (Fig. 2B, Table S6). Here, UFM1 is linked to Alzheimer disease.