In multivariable analysis adjusting for age and sex, compared to controls, there were significantly (P < 0.025 considered significant) higher levels of soluble UFM1 in the temporal cortex (P = 0.017), higher levels of insoluble UFSP2 in the frontal cortex (P = 0.017), as well as higher levels of both soluble (P = 0.002) and insoluble UFM1 (P < 0.001) in the frontal cortex of AD patients (Table 1). The gene discussed is UFM1; the disease is Alzheimer disease.