NFE2L2 and Parkinson disease: To manifest the contribution of the Nrf2/HMOX1 pathway in PD-linked ferroptosis, we employed Oltipraz (Nrf2 agonist), ML385 (Nrf2 inhibitor), Hemin (HMOX1 agonist) and ZNPP (HMOX1 inhibitor) as positive controls, respectively, which were used as positive control.