To manifest the contribution of the Nrf2/HMOX1 pathway in PD-linked ferroptosis, we employed Oltipraz (Nrf2 agonist), ML385 (Nrf2 inhibitor), Hemin (HMOX1 agonist) and ZNPP (HMOX1 inhibitor) as positive controls, respectively, which were used as positive control. Here, HMOX1 is linked to Parkinson disease.