In a colon adenocarcinoma study, ATP6V1C2 knock-down (KD) affected WNT pathway-related genes and epithelial-to-mesenchymal transition (EMT)-related genes, with a decrease in fibronectin-1, vimentin and increase in E-Cadherin, thus attenuating metastasis [182]. The gene discussed is FN1; the disease is colon adenocarcinoma.