MAPT and Alzheimer disease: An AD diagnosis was confirmed on CSF analysis (increased total tau of > 1300 pg/mL (normal < 545 pg/mL) influenced by acute neuronal damage, increased phospho-tau of 84 pg/mL (normal < 75 pg/mL), Aβ 1–42 of 328 pg/mL, Aβ 1–40 of 5585 pg/mL and a decreased Aβ 1–42/1–40 ratio of 0.059 (normal > 0.096) [18].