We then studied and found that CD2AP levels were also significantly increased in the hippocampal tissues of 5- (Fig. 1E) and 7-month-old (Fig. 1B), but not those of 1.5–2 month-old (Fig. 1C and Supplemental Fig. 7A) 5xFAD mice, an AD model carrying five familial AD mutations [54], suggesting that the change of CD2AP expression in the hippocampal tissues of 5xFAD mice is dynamic and dependent on amyloid pathology development. The gene discussed is CD2AP; the disease is Alzheimer disease.