Consistent with previous findings showing that CSF1R expression was elevated in the brain of AD patients and mouse models [80, 81], we also noticed that CSF1R expression was increased in 5xFAD mice and this increase was reversed by microglial CD2AP haploinsufficiency, probably because CD2AP deficiency reduces microgliosis under pathological conditions. The gene discussed is CD2AP; the disease is Alzheimer disease.