The fact that the highly aggressive, Du-145 and PC-3, PCa cell lines do not have functional GJC or hemichannel activity but do express certain Cxs such as Cx26, Cx43, Cx40 and Cx45 suggests that these isoforms could be fulfilling roles that could be independent of their capacity to form channels. Here, GJA5 is linked to posterior cortical atrophy.