ANGPT1 and endothelial dysfunction: To ease clinical identification of these AKI sub-phenotypes, we developed and validated a 3-variable model that included plasma markers of endothelial dysfunction (angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2)) and inflammation (soluble tumor necrosis factor receptor-1 (sTNFR-1)).