AKT1 and cancer: The enriched pathways indicated by the significant DEGs in the FFV PEV-treated MV3 spheroids were protein processing in the ER, C-type lectin receptor signaling pathway, antigen processing and presentation, phosphotylinosital 3 kinase/ protein kinase B (PI3K-Akt) signaling pathway, focal adhesion, ECM-receptor interaction, phospholipase D and NF-kappa B signaling pathways, proteoglycans in cancer and lysosome (Fig. 6B).