CRP and cancer: Another cancer mechanism-related observation, the downregulation of oxidative phosphorylation in the A2058 spheroids by CRP and FFV PEVs at 6 h (and in the MV3 spheroids by CRP PEVs at 6 h) might be indicative of the Warburg effect, wherein cancer cells preferentially shift from oxidative phosphorylation to glycolysis to optimize nutrient acquisition [51].