AKT1 and cancer: The enriched pathways indicated by the significant DEGs in the CRP PEV-treated spheroids were microRNAs in cancer, mitogen-activated protein kinase (MAPK) signaling pathway, protein processing in the ER, proteoglycans in cancer, HIF-1, and PI3K-Akt signaling pathways, central carbon metabolism in cancer, EGFR tyrosine kinase inhibitor resistance, phospholipase D and relaxin signaling pathways (Fig. 6B).