Numerous evidence showed that focal adhesion kinase (FAK, encoded by PTK2) serves as a mechanical connection to the ECM and acts as a biochemical signal hub to direct numerous signal proteins such as PI3K/AKT signalling and plays an important role in many biological processes, including fibrosis, inflammation and tumour metastasis [28, 52, 53]. The gene discussed is AKT1; the disease is neoplasm.