METTL3 and nasopharyngeal carcinoma: In contrast to METTL3, METTL14 [57, 58, 63, 72], WTAP [57, 58, 63, 73], and VIRMA [63, 74, 75] are consistently upregulated in NPC compared to normal NPE tissues, and their high expression levels are associated with poor prognosis (Fig. 1A).