SOX2 and nasopharyngeal carcinoma: In NPC, the super-enhancer lncRNA SUCLG2-AS1, stabilized by METTL3-mediated m6A modification and IGF2BP3, enhances CTCF occupancy at the SOX2 promoter and enhancers, boosting SOX2 transcription through the formation of long-range chromatin loops, thereby promoting NPC metastasis and increasing radiosensitivity [71] (Table 1).