Similarly, m5C writers such as NOP2, NSUN2, and the tRNA m7G writer METTL1/WDR4 are significantly upregulated in NPC, highlighting widespread changes in the epitranscriptomic landscape and supporting the idea that RNA hypermethylation plays a key role in NPC pathogenesis. This evidence concerns the gene METTL1 and nasopharyngeal carcinoma.