Interestingly, spontaneous iASPP mutations identified in cancer patients do not show an aggregation phenotype suggesting that a potential role of mutant iASPP in tumorigenesis is based on different molecular mechanisms than the aggregation inducing germline mutations in cardiocutaneous syndromes. The gene discussed is PPP1R13L; the disease is Microcephaly - facio-cardio-skeletal syndrome, Hadziselimovic type.