ELAVL1 and neuroblastoma: Indeed, while the cleavage of GFP-HuR was observed in HeLa cells treated with the apoptosis-inducing chemotherapeutic drug doxorubicin (Figs. S1D and 1D, E) or in neuroblastoma cells treated with STS (Fig. S2), these effects are negated due to the V225I mutation.