MACC1 and non-small cell lung carcinoma: We found that all of the primary NSCLC specimens have a noticeable increase of MACC1 protein but decrease of KLF4 expression as compared to paired normal lung tissues, indicating that the level of KLF4 is negatively correlated to the level of MACC1 in patient samples (R2 = 0.4038, p = 0.0026) (Fig. 4E, F).