ALDH1A1 and cancer: Epigenetic mechanisms such as DNA methylation, histone modification, etc. can also lead to changes in cell phenotype, transforming non-CSCs into CSCs, the ovarian CSC subpopulation may be preserved through cancer cell dedifferentiation, and DDB2 can prevent the transformation of non-CSCs into CSCs by suppressing ALDH1A1 transcription [11].