IL1B and functional neutrophil defect: These pathways are now established as integral to the pathogenesis of common inflammatory skin disorders, such as psoriasis, characterized by Th17 involvement6–8, atopic dermatitis (AD), characterized by Th2 involvement9–11, lichen planus (LP), characterized by Th1 involvement12, lupus erythematosus (LE), a type I IFN-related disorder13,14, and neutrophilic diseases, influenced by cytokines of the IL-1 family15.