Neutrophilic diseases predominantly expressed genes related to neutrophils with expressions of PECAM1 (receptor involved in neutrophil transmigration), IL-1B and IL-6 (regulator of neutrophil trafficking), CR1, TNFAIP6, MME (neutrophil receptors and molecules), RUNX1, SPP1 (neutrophil attracting chemokine), neutrophil-secreted chemokines (CCL3, CCL4). Here, SPP1 is linked to functional neutrophil defect.