While COXs- and LOXs-mediated metabolites of arachidonic acid were extensively investigated in BC [20, 21], a systemic nontargeted metabolomics of PUFAs metabolism has never been applied to the study of BC, in particular, the mechanisms and signal pathways involving CYP-mediated metabolites in the development of breast cancer remain poorly elucidated. The gene discussed is PPIG; the disease is breast cancer.