The activation of RAS/MAPK and PI3K/AKT pathways by HRG-ERBB2-ERBB3 or HRG-EGFR-ERBB3 complexes led to an abundance of C-MYCS62 phosphorylation in both EML4-ALK-driven NSCLC cell lines (Supplementary Fig. S9A, B). Here, EML4 is linked to non-small cell lung carcinoma.