In the EML4-ALK-negative NSCLC cell line, ERL and SAP let to a reduction of ERKT202/Y204 and AKTS473 phosphorylation, whereas ALK inhibition did not alter MAPK and PI3K/AKT signalling pathways (Supplementary Fig. S11E, F). Here, EML4 is linked to non-small cell lung carcinoma.