Because ERBB family members were one of the most upregulated class of proteins found in our peptide assay, we determined how the tyrosine kinase inhibitors (TKIs), ERL and SAP against EGFR and ERBB2/ERBB3, respectively, affect EML4-ALK-positive NSCLC cell lines (Fig. 3A, D) (Table 1). This evidence concerns the gene ALK and non-small cell lung carcinoma.