The top 10 key target proteins were IL6, IL10, TNF, IL1B, CXCL8, IL1A, CCL2, CSF2, CSF3, and CCL5, which were considered to be OA-enhanced core targets of aspirin therapy for CRC, and the key sub-network of OA-aspirin-CRC is shown in Fig. 1B(c). This evidence concerns the gene CSF3 and colorectal carcinoma.