The experimental results indicated that the phosphorylation of AKT and NFκB1 was inhibited, while the expression of COX2 protein was decreased in the cells treated with OA, Asp and their combination, and the mechanism may be through the inhibition of the activation of PI3K/AKT signaling pathway and NF-κB signaling pathway; and at the same time downregulation of the expression of COX2 protein, which can inhibit the proliferation and survival of cancer cells. This evidence concerns the gene PIK3CA and cancer.