When colon cancer cells were treated with OA, Asp and OA + Asp, a large number of cells accumulated in the S-phase of the cell cycle, and S-phase arrest was correlated with an increase in the expression of p53 and p21 proteins, suggesting that DNA damage activation of cell cycle checkpoint proteins and consequently induced S-phase arrest of the cell cycle occurred. Here, TP53 is linked to malignant colon neoplasm.