Indeed, in contrast to ferroptosis induction in ELF3OV/+ in comparison with wild-type control mouse lungs (Fig. 2), ferroptosis was inhibited by overexpression of ELF3 under PTEN deficiency background both in mice (Fig. 4C, D) and in human lung epithelial cells H1650 (Fig. 4E) and human lung cancer cells NL20 (Fig. 4F), as demonstrated by ferroptosis characteristics, such as the decreased DAB staining and MDA expression or the increased GSH expression (Fig. 4). This evidence concerns the gene ELF3 and lung cancer.