Indeed, we confirmed the induced expression of SLC7A11 in mice (Fig. 5E, F), human bronchial epithelial cells NL20 (Figs. 5G and S1F), and lung cancer cells H1650 Fig. S1E, G) with the background of ELF3 overexpression and PTEN deficiency. The gene discussed is PTEN; the disease is lung cancer.