Moreover, increased tumor growth in the presence of Hpa2-KO macrophages was associated with extensive staining of CD206 that mark M2 macrophages (Fig. 7B, upper panels), whereas decreased tumor growth in the presence of WT macrophages was associated with the recruitment of NK cells that were not detected in SiHa+Hpa2-KO tumors (Fig. 7B, second panels). This evidence concerns the gene HPSE2 and neoplasm.