The inflammatory response was also attenuated in the Slc25a21AAV9 AKI kidney, which had lower renal expression of Interleukin-1 (IL-1β), Interleukin-6 (IL-6), Interleukin-18 (IL-18), Tumor necrosis factor α (TNFα) and Monocyte chemoattractant protein 1 (MCP1) than NCAAV9 mice after cisplatin treatment (Fig. 2H), which was mirrored by a reduction in circulating IL-18 and TNFα levels (Fig. S2H). Here, IL18 is linked to acute kidney injury.