TOMM40 and Parkinson disease: To investigate the impact of α-Syn accumulation under oxidative stress on OMM proteins, we evaluated the effects of PD-associated neurotoxins and pro-oxidant metals—known for generating mitochondrial and cytosolic ROS and fostering α-Syn aggregation in PD models—on the levels of TOM40 and TOM20 (Fig. 2A) [11, 48, 49].