Notably, one third of the DEGs classified as the ‘eye & retina’ category are either directly connected to retinoblastoma (NR2E3, RS1, PRPH2) or cone markers (PDE6H, ARR3, HRASLS) and 45% of the DEGs in the ‘eye & retina’ category also belong to the ‘G-protein’ group of genes (ARR3, PDC, RGS16, GNGT2, RGS9). This evidence concerns the gene RGS16 and retinoblastoma.