Although we demonstrated that tumor growth suppression by senolysis induction using a combination of CDK4/6i and GLS1i is durable using long-term colony formation assay (Fig. 2E), subsequent research evaluating the lifespan of mice bearing BrafV600E melanoma following treatment with CDK4/6i and GLS1i could yield a more accurate assessment of this therapeutic regimen. This evidence concerns the gene CDK4 and melanoma.