RENBP and early-onset autosomal dominant Alzheimer disease: The top five significantly enriched pathways included protein digestion and absorption (P = 1.45 × 10−13), integrin signaling pathway (P = 6.62 × 10−13), extracellular matrix (ECM) receptor interaction (P = 1.01 × 10−5), AGE-RAGE signaling pathway during diabetic complications (P = 2.99 × 10−5), and Alzheimer’s disease-presenilin pathway (P = 6.00 × 10−5) (Fig. 3D).