Phosphatase 2 A catalytic subunit (PP2Ac), a target of cisplatin, inhibits the accumulation of LC3 II and restores p62, and knockdown of PP2Ac promotes autophagy in cisplatin-resistant ovarian cancer cells, suggesting that protective autophagy inhibited by PP2Ac is also a partial mechanism of cisplatin resistance in ovarian cancer [43]. The gene discussed is PPP2CA; the disease is ovarian carcinoma.