To demonstrate the mechanism of association between LOC730101, autophagy and DNA damage, we examined the regulatory relationship between LOC730101 and histone H2A ubiquitination before and after drug treatment by Western Blot and showed that H2AK119ub increased in ovarian cancer cells after treatment with cisplatin or niraparib, respectively, while knockdown LOC730101 was significantly increased in ovarian cancer cells with H2AK119ub compared to control (Fig. 7C), suggesting that LOC730101 can be involved in DNA damage repair through inhibition of histone H2A ubiquitination. The gene discussed is ENSG00000291006; the disease is ovarian cancer.