In agreement with these observations in AAV8-Adipoq-Serpina3c mice, the lipid metabolism disorders caused by Serpina3c KO were also alleviated in AAV8-mediated Hif1α KD mice on a Serpina3c KO mouse background (Figures 7 and 8, Supplementary Figure S7). This evidence concerns the gene HIF1A and Disorder of lipid metabolism.