Drug transporterexpression is prevalently elevated in CML, acute myeloid leukemia(AML), and different solid cancers.9,10 Since frequentlyapplied anticancer agents are substrates of transporter proteins,such as ABCB1, their efflux may drastically decrease intracellulardrug concentrations and result in a poor response to therapy.11 The gene discussed is ABCB1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.