RACK1 is involved in a plethora of key biological events.16,19,29 It has been identified as the scaffold protein for different isoforms of the activated PKC, and the RACK1–PKCβII complex plays an important role in the innate immune response.21–30 Given that RACK1 is also involved in maintaining the integrity of the intestinal epithelial barrier,33 we first evaluate its expression in GI tissues from healthy and IBD patients, who exhibited a deficiency in RACK1 expression, which was significant UC, whereas in quiescent UC patients, specifically in IECs, RACK1 expression was found upregulated. The gene discussed is RACK1; the disease is inflammatory bowel disease.