MYC and neoplasm: Our results showing that treatment of Vκ*-MYC mice with cyclosporine, twice weekly beginning 7 d after C3d injection, inhibited C3d-induced decrease in tumor load (Fig. 2 G–I) while having no effect in splenic plasma cells (Fig. 2J), are consistent with the concept that C3d protein recruited CMI to surveil and clear malignant clones.