Moreover, previous literature studies suggested that a low dose of Sirt1 activator such as resveratrol treatment in rats for 25-day treatment under 5% dextran sulphate sodium-induced colitis condition led to alterations in gut microbiota profile with increased lactobacilli and bifidobacteria alongside a reduced abundance of enterobacteria (Lakhan and Kirchgessner, 2011; Larrosa et al., 2009). Here, SIRT1 is linked to colitis.