(A) Representative image of haematoxylin-eosin-stained liver sections to assess the liver tissue architecture upon Salmonella infection on fifth days post-infection in different mice cohorts (UI, uninfected; STM, S. Typhimurium-infected, EX-527-SIRT1 inhibitor, 3TYP-SIRT3 inhibitor, SRT1720- SIRT1 activator, vehicle control, PBS containing 0.1% DMSO). The gene discussed is SIRT3; the disease is infection.