Along the course of infection, there was a reduction in the expression of M1 markers like Nos2, Cd40,Cd86, Tnfa, Nfkb2, Il6 and a corresponding increase in the expression of the M2 markers such as Arg1, Ccl17, Cd206, IL4ra with an exception of Tgfb (Figure 3A). Here, CD40 is linked to infection.