The main targets against the cognitive declines in AD pathology were AChE in cholinergic hypothesis (McGleenon et al. 1999; Craig et al. 2011; Čolović et al. 2013) and the different forms of Aβ1 − 42 peptides aggregations in amyloid cascade hypothesis (Querfurth and LaFerla 2010; Selkoe and Hardy 2016). The gene discussed is ACHE; the disease is Alzheimer disease.