Therefore, in this study, hispolon (No.1) and its six structural analogs (No.2 to No.7), including one additional hydroxy group at phenyl ring of C-2 or C-5 or different amounts methoxy groups at phenyl ring of hispolon, were used to determine multifaceted targets associated with AD pathologies, including DPPH radical scavenging activity, oxygen radical absorbance capacity (ORAC), anti-nitric oxide productions, AChE inhibitory activities, and anti-Aβ1 − 42-peptide aggregations. Here, ACHE is linked to Alzheimer disease.