NEFL and Alzheimer disease: The NGF was reported to be the key modulators of neurite outgrowths during nervous developments, the insufficiency of NGF might associate with AD, and the flavonol aglycone of isorhamnetin showed similar NGF activities to promote PC12 neurite outgrowths by protein over-expressions of different molecular weights of neurofilaments (NFs), such as NF68, NF160, and NF200 (Xu et al. 2012).