Investigating the specific role of lysosomal TFEB in AD pathogenesis by manipulating the vacuolar ATPase (v‐ATPase) transcriptional program has further demonstrated that the lysosomal TFEB pathway is essential for maintaining lysosomal pH and homeostasis under physiological conditions and the induction of microglia activation in response to tau pathology.26 Here, MAPT is linked to Alzheimer disease.