It is well-established that fluctuations in LH and FSH influence ovarian morphology (Egbert et al. 2019) and adrenal steroidogenesis (Kero et al. 2000); however, under stress conditions such as diet-induced obesity, local effects of gut hormones may also contribute to the regulation of these processes. The gene discussed is PLOD1; the disease is obesity due to melanocortin 4 receptor deficiency.