Previous studies have demonstrated that piRNAs hold significant promise as potential prognostic biomarkers and therapeutic targets for LUAD as well as NSCLC.[11, 12] piR‐651 is elevated in lung cancer tissues, promoting metastasis and viability in LUAD cells while reducing G0/G1 phase arrest.[13] The RASSF1C‐PIWIL1‐piRNA signaling axis, which includes piR‐52200, piR‐35127, piR‐34871, and piR‐46545, plays a crucial role in modulating lung cancer cell proliferation, invasion, migration, and apoptosis.[14] In contrast, some piRNAs function as tumor suppressors. This evidence concerns the gene PIWIL1 and lung cancer.