This disruption in recycling leads to a diminished effector function of cytotoxic T‐lymphocytes.[49] Oxysterols secreted by cancer cells inhibit dendritic cells' ability to present tumor antigens to T cells by reducing the expression of C‐C chemokine receptor type 7.[50] Wang et al. reported that cholesterol directly binds to PD‐L1 protein and enhances its expression in colon and leukemia cell lines.[30] Our study consistently verified that piRNA‐137463 can enhance the PD‐L1 expression in LUAD cells by decreasing its ubiquitination‐proteasome degradation and increasing its stability. This evidence concerns the gene CD274 and neoplasm.