Compared with the Anta‐137463+siNC group (III), the Anta‐137463+siLOC group (IV) exhibited an increased tumor burden (Figure 6B–D) and higher expression of SREBP2, FLOT1, and Ki67, but lower INSIG1 expression (Figure S11, Supporting Information), suggesting that the effects of piRNA‐137463 depletion on tumor growth and cholesterol biosynthesis were dependent on LOC100128494. This evidence concerns the gene INSIG1 and neoplasm.