This disruption in recycling leads to a diminished effector function of cytotoxic T‐lymphocytes.[49] Oxysterols secreted by cancer cells inhibit dendritic cells' ability to present tumor antigens to T cells by reducing the expression of C‐C chemokine receptor type 7.[50] Wang et al. reported that cholesterol directly binds to PD‐L1 protein and enhances its expression in colon and leukemia cell lines.[30] Our study consistently verified that piRNA‐137463 can enhance the PD‐L1 expression in LUAD cells by decreasing its ubiquitination‐proteasome degradation and increasing its stability. Here, CD274 is linked to cancer.