LCT and cryopyrin-associated periodic syndrome: Underlying possible precipitants of CAPS also need to be aggressively treated.64 The combined regimen of immunosuppression, plasma exchange, and therapeutic anticoagulation significantly improved survival and recovery of CAPS in one study (62% vs 23%, p = .014).64 DOAC therapy should be avoided in triple positive APS, with combined LAC, aCL and aB2GPI positivity, due to high risk of recurrent thrombosis and warfarin is favored in this setting.65, –67 Vitamin K antagonists and DOACs are contraindicated during pregnancy.68