A study analyzing the expression of ER stress markers in abdominal aorta samples from abdominal aortic aneurysm (AAA) patients (n = 96) and healthy controls (n = 17) revealed that IRE1α/XBP1s levels are significantly greater in patients with AAA than in healthy controls, and the differences remained statistically significant after adjusting for age, sex, smoking status, hypertension status, and diabetes status.122. Here, ERN1 is linked to Hypertension.