It will be important to expand these studies into investigating the role of MARCKS using animal models of disease such as examining changes in MARCKS‐mediated signaling and function in vascular preparations from systemic and pulmonary artery hypertensive models, for example, spontaneous hypertensive rats, Ang II‐induced hypertensive mice, hypoxia‐ or monocrotaline‐induced pulmonary hypertension rats. The gene discussed is MARCKS; the disease is pulmonary hypertension.