Due to the infertility observed in HSP90α KO mice, we employed clodronate liposomes to deplete macrophages in mice, and subsequently reintroduced HSP90α KO macrophages into the mice via intravenous injection through the tail vein, thereby mimicking the HSP90α KO phenotype as closely as possible (Fig. 8H). The gene discussed is HSP90AA1; the disease is Infertility.