Additionally, MDSCs promote the induction of Tregs and M2 tumor-associated macrophages (M2-TAMs) and inhibit immune effector cells, such as CD8+ T cells, DCs, and natural killer (NK) cells, further undermining the immune response against tumors [25]; Tregs perform their suppressive role by releasing inhibitory cytokines, notably transforming growth factor-β (TGF-β) and interleukin-10 (IL-10). This evidence concerns the gene IL10 and neoplasm.