Importantly, the comparison of CD4+ T cells in CCI versus rapid recovery sepsis survivors revealed 9 differentially upregulated genes in CCI that are associated with cell activation and proliferation (CD4, CD27, CEBPB, DHPS, SLAMF1, LAPTM5, FADD, RASAL3, and TMIGD2) (71). The gene discussed is TMIGD2; the disease is Sepsis.