CXCL8 and neoplasm: While cDCs inhibit tumor angiogenesis and promote M2-type TAM polarization by secreting anti-angiogenic factors such as IL-12, IL-18, CXCL9, CXCL10, and CCL21 (73–75), tumor-associated pDCs induce angiogenesis by secreting TNFα and IL-8 (73).