VEGFA and neoplasm: Tumor cells and other cells within the tumor microenvironment (TME) secrete various angiogenic factors, such as the vascular endothelial growth factor (VEGF), fibroblast growth factors (FGFs), platelet-derived growth factors (PDGFs), etc. These factors, upon binding to their receptors, activate endothelial cells (ECs) to cause morphological changes in the basement membrane and the surrounding extracellular matrix (ECM), thereby promoting the formation of new blood vessels.