MYOM2 and POEMS syndrome: Firstly, limited levels of detection: serum protein electrophoresis (sPEP), immunofixation electrophoresis (sIFE), and serum free light chain (sFLC), as the main methods for the detection of M protein, have improved the diagnosis of malignant plasma cell disease; however, in patients with POEMS syndrome, there are still cases of negative M protein assays (10).