(37) suggest the following: Numb controls the migration of epithelial cells by regulating intercellular connectivity, and the inhibition of the expression of Numb can promote the migration and invasion of colon cancer cells induced by TGF-β, upregulate the expression of EMT-related molecule Snail, inhibit the expression of E-cadherin, resulting in the destruction of intercellular links, and participate in the invasion and metastasis of colon cancer cells. Here, NUMB is linked to malignant colon neoplasm.