NOTCH1 and malignant colon neoplasm: This study showed that the expression of Notch-1 protein in colon cancer tissues was significantly higher than that in adjacent tissues (p < 0.05), suggesting that the high expression of Notch-1 leads to abnormal activation of Notch signaling pathway, which may be involved in the occurrence and development of colon cancer and play a role in promoting cancer, which is consistent with Xu et al.