NOTCH1 and malignant colon neoplasm: In this study, it was found that the positive expression rate of Notch-1 was higher in colon cancer tissues with poor differentiation types (p < 0.05), suggesting that the expression of Notch-1 is related to the differentiation types of colon cancer and may be involved in cell differentiation, which is closely related to the occurrence and development of colon cancer.