In this study, it was found that the expression of Numb in para-cancerous tissues was significantly higher than that in cancerous tissues and metastatic lymph nodes (p<0.05) and was related to the degree of tissue differentiation, presence or absence of lymph node metastasis, and TNM stage (p<0.05), but not related to tumor size and presence or absence of envelope invasion (p>0.05). Here, NUMB is linked to neoplasm.