In ccRCC, circPOLR2A acts as an oncogene closely correlated with malignancy, and YTHDF2 suppresses circPOLR2A expression in an m6A-dependent manner, where the circPOLR2A/PEBP1 axis positively affects angiogenesis in ccRCC (186). Here, PEBP1 is linked to nonpapillary renal cell carcinoma.