They have a unique three-lipid (Triacyl) chain except for mycobacteria, which have two-lipid chain (diacyl).134 An essential feature of this ligand is the presence of a hydrophobic pocket that interacts with lipid chains, which allow variation in the length and chemical structure of lipids.135 In parasitic infection, GPI is activated by TLR-2. Here, TLR2 is linked to parasitic infectious disease.