Large amino acid transporter 1 (LAT1, SLC7A5)is part of a system providing essential nutrients to cells.12,13 LAT1 forms a complex with 4F2 heavy chain (4F2hc, SLC3A2),12 stabilizing and facilitating LAT1’sfunction on the plasma membrane.14 LAT1transports neutral amino acids across biological barriers, e.g., theblood–brain barrier (BBB),15 andhas been shown to be highly expressed in several cancers, includingglioblastoma and head and neck cancers. Here, SLC3A2 is linked to head and neck cancer.