Here, we stained peripheral blood CLL cells for ki67 and DNA content and found that CLL cells in G1‐phase have a CXCR4loCD5hi phenotype, while CLL cells in S/G2/M‐phase express high levels of both CXCR4 and CD5. The gene discussed is CXCR4; the disease is B-cell chronic lymphocytic leukemia.