Curcumin reverses Aβ42‐induced impairments in phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (Akt) signaling, a pathway that suppresses glycogen synthase kinase‐3beta (GSK‐3β) activity, in rat models of AD.20, 46. This evidence concerns the gene GSK3B and Alzheimer disease.